| First Author | Lee KE | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 12 | Pages | 3457-3464 |
| PubMed ID | 29924990 | Mgi Jnum | J:271002 |
| Mgi Id | MGI:6278370 | Doi | 10.1016/j.celrep.2018.05.071 |
| Citation | Lee KE, et al. (2018) Hif1alpha Deletion Limits Tissue Regeneration via Aberrant B Cell Accumulation in Experimental Pancreatitis. Cell Rep 23(12):3457-3464 |
| abstractText | Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor 1alpha (HIF1alpha) transcription factor occur in murine and human pancreatitis. Mice lacking pancreas-specific HIF1alpha expression display markedly impaired pancreatic regeneration following cerulein-induced pancreatitis, which is associated with excessive intrapancreatic B cell accumulation. Notably, B cell depletion in mice with established pancreatitis significantly enhances tissue regeneration. Our study reveals a crosstalk between pancreatic HIF1alpha expression and B cell trafficking that regulates tissue regeneration, and identifies plausible molecular targets for treating pancreatitis patients. |
