| First Author | Cho Y | Year | 2015 |
| Journal | Neuron | Volume | 88 |
| Issue | 4 | Pages | 720-34 |
| PubMed ID | 26526390 | Mgi Jnum | J:228750 |
| Mgi Id | MGI:5708789 | Doi | 10.1016/j.neuron.2015.09.050 |
| Citation | Cho Y, et al. (2015) Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1alpha. Neuron 88(4):720-34 |
| abstractText | Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1alpha (HIF-1alpha) controls multiple injury-induced genes in sensory neurons and contribute to the preconditioning lesion effect. Knockdown of HIF-1alpha in vitro or conditional knock out in vivo impairs sensory axon regeneration. The HIF-1alpha target gene Vascular Endothelial Growth Factor A (VEGFA) is expressed in injured neurons and contributes to stimulate axon regeneration. Induction of HIF-1alpha using hypoxia enhances axon regeneration in vitro and in vivo in sensory neurons. Hypoxia also stimulates motor neuron regeneration and accelerates neuromuscular junction re-innervation. This study demonstrates that HIF-1alpha represents a critical transcriptional regulator in regenerating neurons and suggests hypoxia as a tool to stimulate axon regeneration. |
