| First Author | Doktorova M | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 846 |
| PubMed ID | 28404991 | Mgi Jnum | J:275117 |
| Mgi Id | MGI:6296122 | Doi | 10.1038/s41598-017-00889-z |
| Citation | Doktorova M, et al. (2017) Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep 7(1):846 |
| abstractText | Peroxisome proliferator-activated receptor delta (PPARdelta) is a ligand-activated transcription factor that has an important role in lipid metabolism. Activation of PPARdelta stimulates fatty acid oxidation in adipose tissue and skeletal muscle and improves dyslipidemia in mice and humans. PPARdelta is highly expressed in the intestinal tract but its physiological function in this organ is not known. Using mice with an intestinal epithelial cell-specific deletion of PPARdelta, we show that intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. Furthermore, absence of intestinal PPARdelta abolished the ability of PPARdelta agonist GW501516 to increase plasma levels of HDL-cholesterol. Together, our findings show that intestinal PPARdelta is important in maintaining metabolic homeostasis and suggest that intestinal-specific activation of PPARdelta could be a therapeutic approach for treatment of the metabolic syndrome and dyslipidemia, while avoiding systemic toxicity. |
