| First Author | Chawla A | Year | 2003 |
| Journal | Proc Natl Acad Sci U S A | Volume | 100 |
| Issue | 3 | Pages | 1268-73 |
| PubMed ID | 12540828 | Mgi Jnum | J:81838 |
| Mgi Id | MGI:2450061 | Doi | 10.1073/pnas.0337331100 |
| Citation | Chawla A, et al. (2003) PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A 100(3):1268-73 |
| abstractText | Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor delta. The signaling components of native VLDL are its triglycerides, whose activity is enhanced by lipoprotein lipase. Generation of peroxisome proliferator-activated receptor delta null macrophages verifies the absolute requirement of this transcription factor in mediating the VLDL response. Thus, our data reveal a pathway through which dietary triglycerides and VLDL can directly regulate gene expression in atherosclerotic lesions. |
