| First Author | Qian SW | Year | 2016 |
| Journal | EBioMedicine | Volume | 11 |
| Pages | 91-100 | PubMed ID | 27522322 |
| Mgi Jnum | J:260428 | Mgi Id | MGI:6150532 |
| Doi | 10.1016/j.ebiom.2016.07.034 | Citation | Qian SW, et al. (2016) BMP4 Cross-talks With Estrogen/ERalpha Signaling to Regulate Adiposity and Glucose Metabolism in Females. EBioMedicine 11:91-100 |
| abstractText | Similar to estrogens, bone morphogenetic protein 4 (BMP4) promotes the accumulation of more metabolically active subcutaneous fat and reduction of visceral fat. However, whether there is a cross-talk between BMP4 and estrogen signaling remained unknown. Herein, we found that BMP4 deficiency in white adipose tissue (WAT) increased the estrogen receptor alpha (ERalpha) level and its signaling, which prevented adult female mice from developing high fat diet (HFD)-induced obesity and insulin resistance; estrogens depletion up regulated BMP4 expression to overcome overt adiposity and impaired insulin sensitivity with aging, and failure of BMP4 regulation due to genetic knockout led to more fat gain in aged female mice. This mutual regulation between BMP4 and estrogen/ERalpha signaling may also happen in adipose tissue of women, since the BMP4 level significantly increased after menopause, and was inversely correlated with body mass index (BMI). These findings suggest a counterbalance between BMP4 and estrogen/ERalpha signaling in the regulation of adiposity and relative metabolism in females. |
