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Publication : Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization.

First Author  Liu P Year  2019
Journal  Nat Commun Volume  10
Issue  1 Pages  5070
PubMed ID  31699980 Mgi Jnum  J:282234
Mgi Id  MGI:6378136 Doi  10.1038/s41467-019-12988-8
Citation  Liu P, et al. (2019) Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating beta3-AR desensitization. Nat Commun 10(1):5070
abstractText  beta-Adrenergic receptor (beta-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and thermogenesis. Adipose-specific deletion of Foxp1 leads to an increase of brown adipose activity and browning program of white adipose tissues. The Foxp1-deficient mice show an augmented energy expenditure and are protected from diet-induced obesity and insulin resistance. Consistently, overexpression of Foxp1 in adipocytes impairs adaptive thermogenesis and promotes diet-induced obesity. A robust change in abundance of the beta3-adrenergic receptor (beta3-AR) is observed in brown/beige adipocytes from both lines of mice. Molecularly, Foxp1 directly represses beta3-AR transcription and regulates its desensitization behavior. Taken together, our findings reveal Foxp1 as a master transcriptional repressor of brown/beige adipocyte differentiation and thermogenesis, and provide an important clue for its targeting and treatment of obesity.
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