| First Author | Adams AC | Year | 2012 |
| Journal | Mol Metab | Volume | 2 |
| Issue | 1 | Pages | 31-7 |
| PubMed ID | 24024127 | Mgi Jnum | J:221244 |
| Mgi Id | MGI:5638530 | Doi | 10.1016/j.molmet.2012.08.007 |
| Citation | Adams AC, et al. (2012) The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab 2(1):31-7 |
| abstractText | FGF21 is a multifunctional metabolic regulator. The co-factor betaKlotho (KLB) allows FGF21 to signal via FGF receptors. Given the widespread nature of FGFR expression and KLB presence in several organs, it remains unclear which tissue/FGFR isoform determine FGF21 action. Here we show that deletion of FGFR1 in fat (FR1KO) leads to a complete ablation of FGF21 stimulated transcriptional activity in this tissue. Furthermore, FR1KO mice showed no FGF21-mediated lowering of plasma glucose, insulin and triglycerides, altered serum levels of adipokines, no increase in energy expenditure, but preserved reductions in serum/liver FFAs as compared to wild type mice. Of importance, the anti-glycaemic actions of FGF19 were fully evident in FR1KO mice implying that FGF19 functions in a FGFR1/adipose independent manner. Taken together, our findings reveal the existence of an adipose FGFR1 driven axis of cross-tissue communication which defines several aspects of FGF21 biology and delineates mechanistic distinctions between FGF21 and FGF19. |
