| First Author | Chi TH | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 2 | Pages | 169-82 |
| PubMed ID | 12932351 | Mgi Jnum | J:85191 |
| Mgi Id | MGI:2673061 | Doi | 10.1016/s1074-7613(03)00199-7 |
| Citation | Chi TH, et al. (2003) Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity 19(2):169-82 |
| abstractText | T cells develop through distinct stages directed by a series of signals. We explored the roles of SWI/SNF-like BAF chromatin remodeling complexes in this process by progressive deletion of the ATPase subunit, Brg, through successive stages of early T cell development. Brg-deficient cells were blocked at each of the developmental transitions examined. Bcl-xL overexpression suppressed cell death without relieving the developmental blockades, leading to the accumulation of Brg-deleted cells that were unexpectedly cell cycle arrested. These defects resulted partly from the disruptions of pre-TCR and potentially Wnt signaling pathways controlling the expression of genes such as c-Kit and c-Myc critical for continued development. Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals. |
