| First Author | Gattu S | Year | 2019 |
| Journal | Proc Natl Acad Sci U S A | Volume | 116 |
| Issue | 22 | Pages | 10911-10916 |
| PubMed ID | 31097581 | Mgi Jnum | J:275599 |
| Mgi Id | MGI:6307658 | Doi | 10.1073/pnas.1812069116 |
| Citation | Gattu S, et al. (2019) Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity. Proc Natl Acad Sci U S A 116(22):10911-10916 |
| abstractText | Vitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here we show that epithelial cell expression of the transcription factor retinoic acid receptor beta (RARbeta) is essential for vitamin A-dependent intestinal immunity. Epithelial RARbeta activated vitamin A-dependent expression of serum amyloid A (SAA) proteins by binding directly to Saa promoters. In accordance with the known role of SAAs in regulating Th17 cell effector function, epithelial RARbeta promoted IL-17 production by intestinal Th17 cells. More broadly, epithelial RARbeta was required for the development of key vitamin A-dependent adaptive immune responses, including CD4(+) T-cell homing to the intestine and the development of IgA-producing intestinal B cells. Our findings provide insight into how the intestinal epithelium senses dietary vitamin A status to regulate adaptive immunity, and highlight the role of epithelial cells in regulating intestinal immunity in response to diet. |
