| Primary Identifier | MGI:2386114 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Rorc |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The DNA-binding domain, the hinge domain, and part of the ligand-binding domain (amino acids 25-309) encoded by exons 3-6 were replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of liver, thymus, and kidney tissue using a probe spanning exons 3-6 confirmed the absence of the targeted region in homozygous mutant animals. When analyzed using a full-length Rorc probe 2 species of mutant transcripts, probably due to alternative splicing events, were detected in homozygous mutants. |
