| First Author | Kim S | Year | 2003 |
| Journal | Proc Natl Acad Sci U S A | Volume | 100 |
| Issue | 3 | Pages | 1203-8 |
| PubMed ID | 12538858 | Mgi Jnum | J:81832 |
| Mgi Id | MGI:2450055 | Doi | 10.1073/pnas.0337707100 |
| Citation | Kim S, et al. (2003) The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival. Proc Natl Acad Sci U S A 100(3):1203-8 |
| abstractText | The transcription factor nuclear factor-kappaB (NF-kappaB) is essential for immune and inflammatory responses. NF-kappaB essential modulator (NEMO) is a scaffolding component of the IkappaB kinase complex required for NF-kappaB activation in vitro. Because NF-kappaB activation is involved in B cell development and function, we set out to determine whether NEMO is required for these processes. NEMO(--) mice die very early during embryogenesis, and fetal livers from NEMO(--) embryos can not reconstitute either B or T lymphopoiesis in irradiated host mice. We therefore used NEMO(--) embryonic stem cells and the OP9 in vitro differentiation system to demonstrate that NEMO is not required for B cell development but plays an important role in B cell survival. |
