| First Author | Guvenc B | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 13 | Pages | 2862-6 |
| PubMed ID | 20447398 | Mgi Jnum | J:161323 |
| Mgi Id | MGI:4457990 | Doi | 10.1016/j.febslet.2010.04.070 |
| Citation | Guvenc B, et al. (2010) A dynamic approach reveals non-muscle myosin influences the overall smooth muscle cross-bridge cycling rate. FEBS Lett 584(13):2862-6 |
| abstractText | Recent evidence suggests that non-muscle myosin IIB (NMIIB) contributes to smooth muscle contraction. This study was designed to determine the effects of NMIIB on the cross-bridge cycling rate. The cross-bridge cycling rate was investigated using sinusoidal analysis. Frequency analysis revealed two asymptotes in the Bode plot of the data; and the intersection of the asymptotes (corner frequency) was higher for the B(+/-) strain (8.73+/-1.10 Hz vs 16.56+/-1.26 Hz, P<0.05), consistent with a higher overall cross-bridge cycling rate in heterozygous NMIIB KO (B(+/-)) vs WT mice. These results demonstrate that because of their long duty cycle, NMIIB cross-bridges act as an internal load on smooth muscle myosin to decrease the overall cross-bridge cycling rate and muscle V(max) during force maintenance. |
