| First Author | Wells AC | Year | 2017 |
| Journal | Elife | Volume | 6 |
| PubMed ID | 28737488 | Mgi Jnum | J:258214 |
| Mgi Id | MGI:6116966 | Doi | 10.7554/eLife.26398 |
| Citation | Wells AC, et al. (2017) Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells. Elife 6:e26398 |
| abstractText | The differentiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune responses. Here, using a mouse model, we describe a dual role for the let-7 microRNAs in the regulation of CD8 T cell responses, where maintenance of the naive phenotype in CD8 T cells requires high levels of let-7 expression, while generation of cytotoxic T lymphocytes depends upon T cell receptor-mediated let-7 downregulation. Decrease of let-7 expression in activated T cells enhances clonal expansion and the acquisition of effector function through derepression of the let-7 targets, including Myc and Eomesodermin. Ultimately, we have identified a novel let-7-mediated mechanism, which acts as a molecular brake controlling the magnitude of CD8 T cell responses. |
