| First Author | Wan YY | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 8 | Pages | 851-8 |
| PubMed ID | 16799562 | Mgi Jnum | J:112646 |
| Mgi Id | MGI:3662965 | Doi | 10.1038/ni1355 |
| Citation | Wan YY, et al. (2006) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 7(8):851-8 |
| abstractText | The kinase TAK1 is critical for innate and B cell immunity. The function of TAK1 in T cells is unclear, however. We show here that T cell-specific deletion of the gene encoding TAK1 resulted in reduced development of thymocytes, especially of regulatory T cells expressing the transcription factor Foxp3. In mature thymocytes, TAK1 was required for interleukin 7-mediated survival and T cell receptor-dependent activation of transcription factor NF-kappaB and the kinase Jnk. In effector T cells, TAK1 was dispensable for T cell receptor-dependent NF-kappaB activation and cytokine production, but was important for proliferation and activation of the kinase p38 in response to interleukins 2, 7 and 15. Thus, TAK1 is essential for the integration of T cell receptor and cytokine signals to regulate the development, survival and function of T cells. |
