| First Author | Park HJ | Year | 2016 |
| Journal | Sci Rep | Volume | 6 |
| Pages | 28495 | PubMed ID | 27335315 |
| Mgi Jnum | J:254106 | Mgi Id | MGI:6101712 |
| Doi | 10.1038/srep28495 | Citation | Park HJ, et al. (2016) Gender-specific differences in PPARgamma regulation of follicular helper T cell responses with estrogen. Sci Rep 6:28495 |
| abstractText | Peroxisome proliferator-activated receptor gamma (PPARgamma), a master regulator of adipocyte differentiation, has recently been connected with effector T cells, though its role is still not clear. Here, we investigated the roles of PPARgamma in follicular helper T (TFH) cell responses regarding gender specificity. NP-OVA immunization in female but not male CD4-PPARgamma(KO) mice induced higher proportions of TFH cells and germinal center (GC) B cells following immunization than were seen in wild type mice. Treatment with the PPARgamma agonist pioglitazone significantly reduced TFH cell responses in female mice while pioglitazone and estradiol (E2) co-treatment ameliorated TFH cells and GC responses in male mice. E2 treatment significantly enhanced PPARgamma expression in male T cells, while T cell activation in the estrus but not in the diestrus stage of the menstrual cycle of females was inhibited by pioglitazone, suggesting that an estrogen-sufficient environment is important for PPARgamma-mediated T cell regulation. These results demonstrate gender-based differences in sensitivities of PPARgamma in TFH responses. These findings suggest that appropriate function of PPARgamma is required in the regulation of female GC responses and that therapeutic strategies for autoimmune diseases using PPARgamma agonists need to be tailored accordingly. |
