| First Author | Etzensperger R | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 11 | Pages | 1218-1227 |
| PubMed ID | 28945245 | Mgi Jnum | J:259142 |
| Mgi Id | MGI:6142446 | Doi | 10.1038/ni.3847 |
| Citation | Etzensperger R, et al. (2017) Identification of lineage-specifying cytokines that signal all CD8(+)-cytotoxic-lineage-fate 'decisions' in the thymus. Nat Immunol 18(11):1218-1227 |
| abstractText | T cell antigen receptor (TCR) signaling in the thymus initiates positive selection, but the CD8(+)-lineage fate is thought to be induced by cytokines after TCR signaling has ceased, although this remains controversial and unproven. We have identified four cytokines (IL-6, IFN-gamma, TSLP and TGF-beta) that did not signal via the common gamma-chain (gammac) receptor but that, like IL-7 and IL-15, induced expression of the lineage-specifying transcription factor Runx3d and signaled the generation of CD8(+) T cells. Elimination of in vivo signaling by all six of these ''lineage-specifying cytokines'' during positive selection eliminated Runx3d expression and completely abolished the generation of CD8(+) single-positive thymocytes. Thus, this study proves that signaling during positive selection by lineage-specifying cytokines is responsible for all CD8(+)-lineage-fate ''decisions'' in the thymus. |
