| First Author | Vanderleyden I | Year | 2020 |
| Journal | Cell Rep | Volume | 30 |
| Issue | 3 | Pages | 611-619.e4 |
| PubMed ID | 31968240 | Mgi Jnum | J:288133 |
| Mgi Id | MGI:6415763 | Doi | 10.1016/j.celrep.2019.12.076 |
| Citation | Vanderleyden I, et al. (2020) Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5. Cell Rep 30(3):611-619.e4 |
| abstractText | The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3(+) regulatory T cells located within GCs. Relatively little is known about the exact role of Tfr cells within the GC and how they exert their suppressive function. A unique feature of Tfr cells is their reported CXCR5-dependent localization to the GC. Here, we show that the lack of CXCR5 on Foxp3(+) regulatory T cells results in a reduced frequency, but not an absence, of GC-localized Tfr cells. This reduction in Tfr cells is not sufficient to alter the magnitude or output of the GC response. This demonstrates that additional, CXCR5-independent mechanisms facilitate Treg cell homing to the GC. |
