| First Author | Fu W | Year | 2018 |
| Journal | J Exp Med | Volume | 215 |
| Issue | 3 | Pages | 815-825 |
| PubMed ID | 29378778 | Mgi Jnum | J:259748 |
| Mgi Id | MGI:6120437 | Doi | 10.1084/jem.20170901 |
| Citation | Fu W, et al. (2018) Deficiency in T follicular regulatory cells promotes autoimmunity. J Exp Med 215(3):815-825 |
| abstractText | T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6(fl/fl)Foxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6(fl/fl)Foxp3Cre/Cre mice developed late-onset spontaneous autoimmune diseases, affecting the salivary glands with lymphocyte infiltration and antibody deposition. In a mouse experimental Sjogren''s syndrome model, ablation of Bcl6 in T reg cells greatly enhanced disease development. Conversely, Bcl6(fl/fl)Cd4Cre mice were protected in the model. Thus, our study indicates that Tfr cells control autoimmune diseases and can be targeted in infectious and autoimmune disease. |
