| First Author | Overacre-Delgoffe AE | Year | 2021 |
| Journal | Immunity | Volume | 54 |
| Issue | 12 | Pages | 2812-2824.e4 |
| PubMed ID | 34861182 | Mgi Jnum | J:317580 |
| Mgi Id | MGI:6856563 | Doi | 10.1016/j.immuni.2021.11.003 |
| Citation | Overacre-Delgoffe AE, et al. (2021) Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer. Immunity 54(12):2812-2824.e4 |
| abstractText | The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Here, we examined the impact of microbiota-specific T cells in anti-colorectal cancer (CRC) immunity. Introduction of Helicobacter hepaticus (Hhep) in a mouse model of CRC did not alter the microbial landscape but increased tumor infiltration by cytotoxic lymphocytes and inhibited tumor growth. Anti-tumor immunity was independent of CD8(+) T cells but dependent upon CD4(+) T cells, B cells, and natural killer (NK) cells. Hhep colonization induced Hhep-specific T follicular helper (Tfh) cells, increased the number of colon Tfh cells, and supported the maturation of Hhep+ tumor-adjacent tertiary lymphoid structures. Tfh cells were necessary for Hhep-mediated tumor control and immune infiltration, and adoptive transfer of Hhep-specific CD4(+) T cells to Tfh cell-deficient Bcl6(fl/fl)Cd4(Cre) mice restored anti-tumor immunity. Thus, introduction of immunogenic intestinal bacteria can promote Tfh-associated anti-tumor immunity in the colon, suggesting therapeutic approaches for the treatment of CRC. |
