| First Author | Liston A | Year | 2008 |
| Journal | J Exp Med | Volume | 205 |
| Issue | 9 | Pages | 1993-2004 |
| PubMed ID | 18725526 | Mgi Jnum | J:138807 |
| Mgi Id | MGI:3806416 | Doi | 10.1084/jem.20081062 |
| Citation | Liston A, et al. (2008) Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med 205(9):1993-2004 |
| abstractText | Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell-deficient mice. In disease-free mice lacking Dicer in all T cells or harboring both Dicer-deficient and -sufficient T reg cells, Dicer-deficient T reg cells were suppressive, albeit to a lesser degree, whereas their homeostatic potential was diminished as compared with their Dicer-sufficient counterparts. However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions. |
