| First Author | Xia R | Year | 2020 |
| Journal | Front Cell Dev Biol | Volume | 8 |
| Pages | 834 | PubMed ID | 32984329 |
| Mgi Jnum | J:301727 | Mgi Id | MGI:6506284 |
| Doi | 10.3389/fcell.2020.00834 | Citation | Xia R, et al. (2020) Differential Requirement of Beclin 1 for Regulating the Balance of Naive and Activated CD4(+) T Cells. Front Cell Dev Biol 8:834 |
| abstractText | Autophagy is highly regulated and plays a multitude of roles during T cell-mediated immune responses. It has been shown that autophagy deficiency in T cells results in a decrease in total T cells, including naive T cells in young mice, but the mechanism is still not understood. Here, similar to what happened in young mice, we showed that T cell-specific deletion of Beclin 1/Atg6 (Becn1 -/-) resulted in decreases in the percentages of CD4(+), CD8(+), and regulatory T cells in adult mice. In addition, we found that the effector to naive T cell ratio was increased in older mice. Also, as mice grew older, Becn1 -/- mice progressively lost weight and developed severe colitis. Analysis of inflamed tissues demonstrated increases in the portion and cytokine production of effector T cells. In contrast, the TCR-transgenic Becn1 -/- mice had similar numbers of naive T cells compared to WT controls. Similar to bulk T cells, the TCR-transgenic Becn1 -/- T cells generated much lower numbers of effector T cells compared to WT controls after activation in vitro. These data suggest that autophagy is not required for maintaining the naive T cell but required for the generation of effector T cells in vivo. |
