| First Author | Wang Y | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 7 | Pages | 714-22 |
| PubMed ID | 23708251 | Mgi Jnum | J:204830 |
| Mgi Id | MGI:5543535 | Doi | 10.1038/ni.2623 |
| Citation | Wang Y, et al. (2013) GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling. Nat Immunol 14(7):714-22 |
| abstractText | GATA-3 controls T helper type 2 (TH2) differentiation. However, whether GATA-3 regulates the function of mature T cells beyond TH2 determination remains poorly understood. We found that signaling via the T cell antigen receptor (TCR) and cytokine stimulation promoted GATA-3 expression in CD8(+) T cells, which controlled cell proliferation. Although GATA-3-deficient CD8(+) T cells were generated, their peripheral maintenance was impaired, with lower expression of the receptor for interleukin 7 (IL-7R). GATA-3-deficient T cells had defective responses to viral infection and alloantigen. The proto-oncoprotein c-Myc was a critical target of GATA-3 in promoting T cell proliferation. Our study thus demonstrates an essential role for GATA-3 in controlling the maintenance and proliferation of T cells and provides insight into immunoregulation. |
