| First Author | Takeda K | Year | 1996 |
| Journal | J Immunol | Volume | 157 |
| Issue | 8 | Pages | 3220-2 |
| PubMed ID | 8871614 | Mgi Jnum | J:38364 |
| Mgi Id | MGI:85735 | Doi | 10.4049/jimmunol.157.8.3220 |
| Citation | Takeda K, et al. (1996) Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 157(8):3220-2 |
| abstractText | IL-13 shares many biologic responses with IL-4. In contrast to well-characterized IL-4 signaling pathways, which utilize STAT6 and 4PS/IRS2, IL-13 signaling pathways are poorly understood. Recent studies performed with STAT6-deficient mice have demonstrated that STAT6 plays an essential role in IL-4 signaling. In this study, the functions of peritoneal macrophages of STAT6-deficient mice in response to IL-13 were analyzed. In STAT6-deficient mice, neither morphologic changes nor augmentation of MHC class II expression in response to IL-13 was observed. In addition, IL-13 did not decrease the nitric oxide production by activated macrophages. Taken together, these results suggest that the macrophage functions in response to IL-13 were impaired in STAT6-deficient mice, indicating that IL-13 and IL-4 share the signaling pathway via STAT6. |
