| First Author | Nakamura J | Year | 2022 |
| Journal | MicroPubl Biol | Volume | 2022 |
| PubMed ID | 36601325 | Mgi Jnum | J:339223 |
| Mgi Id | MGI:7520721 | Doi | 10.17912/micropub.biology.000695 |
| Citation | Nakamura J, et al. (2022) Cold shock protein RBM3 is upregulated in the autophagy-deficient brain. MicroPubl Biol 2022 |
| abstractText | Neural autophagy plays an important role in regulating protein quality control, brain homeostasis, and body temperature. However, the mechanism that links a defect in autophagy to body temperature has not been elucidated. Here, we report that RNA binding motif protein 3 (RBM3) is a potential candidate that regulates body temperature. We found that the body temperatures of Nestin-Cre ; Atg7 (f/f) conditional KO (cKO) mice were lower than that of wild-type (WT) mice. Moreover, RBM3 was upregulated in the Nestin-Cre ; Atg7 (f/f) brain. These data suggest that RBM3 is an implicit target that maintains body temperature influenced by neural autophagy. |
