| First Author | Qi L | Year | 2020 |
| Journal | Neurosci Bull | Volume | 36 |
| Issue | 7 | Pages | 685-695 |
| PubMed ID | 32221845 | Mgi Jnum | J:291436 |
| Mgi Id | MGI:6444984 | Doi | 10.1007/s12264-020-00486-7 |
| Citation | Qi L, et al. (2020) Nuclear Factor I/A Controls A-fiber Nociceptor Development. Neurosci Bull 36(7):685-695 |
| abstractText | Noxious mechanical information is transmitted through molecularly distinct nociceptors, with pinprick-evoked sharp sensitivity via A-fiber nociceptors marked by developmental expression of the neuropeptide Y receptor 2 (Npy2r) and von Frey filament-evoked punctate pressure information via unmyelinated C fiber nociceptors marked by MrgprD. However, the molecular programs controlling their development are only beginning to be understood. Here we demonstrate that Npy2r-expressing sensory neurons are in fact divided into two groups, based on transient or persistent Npy2r expression. Npy2r-transient neurons are myelinated, likely including A-fiber nociceptors, whereas Npy2r-persistent ones belong to unmyelinated pruriceptors that co-express Nppb. We then showed that the transcription factors NFIA and Runx1 are necessary for the development of Npy2r-transient A-fiber nociceptors and MrgprD(+) C-fiber nociceptors, respectively. Behaviorally, mice with conditional knockout of Nfia, but not Runx1 showed a marked attenuation of pinprick-evoked nocifensive responses. Our studies therefore identify a transcription factor controlling the development of myelinated nociceptors. |
