| First Author | Shin JE | Year | 2012 |
| Journal | Neuron | Volume | 74 |
| Issue | 6 | Pages | 1015-22 |
| PubMed ID | 22726832 | Mgi Jnum | J:188356 |
| Mgi Id | MGI:5440367 | Doi | 10.1016/j.neuron.2012.04.028 |
| Citation | Shin JE, et al. (2012) Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron 74(6):1015-22 |
| abstractText | Here we demonstrate that the dual leucine zipper kinase (DLK) promotes robust regeneration of peripheral axons after nerve injury in mice. Peripheral axon regeneration is accelerated by prior injury; however, DLK KO neurons do not respond to a preconditioning lesion with enhanced regeneration in vivo or in vitro. Assays for activation of transcription factors in injury-induced proregenerative pathways reveal that loss of DLK abolishes upregulation of p-STAT3 and p-cJun in the cell body after axonal injury. DLK is not required for the phosphorylation of STAT3 at the site of nerve injury but is necessary for retrograde transport of p-STAT3 to the cell body. These data demonstrate that DLK enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program. |
