| First Author | Peng C | Year | 2017 |
| Journal | Science | Volume | 356 |
| Issue | 6343 | Pages | 1168-1171 |
| PubMed ID | 28572455 | Mgi Jnum | J:243640 |
| Mgi Id | MGI:5909339 | Doi | 10.1126/science.aam7671 |
| Citation | Peng C, et al. (2017) miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science 356(6343):1168-1171 |
| abstractText | Nociception is protective and prevents tissue damage but can also facilitate chronic pain. Whether a general principle governs these two types of pain is unknown. Here, we show that both basal mechanical and neuropathic pain are controlled by the microRNA-183 (miR-183) cluster in mice. This single cluster controls more than 80% of neuropathic pain-regulated genes and scales basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gated calcium channel subunits alpha2delta-1 and alpha2delta-2. Basal sensitivity is controlled in nociceptors, and allodynia involves TrkB+ light-touch mechanoreceptors. These light-touch-sensitive neurons, which normally do not elicit pain, produce pain during neuropathy that is reversed by gabapentin. Thus, a single microRNA cluster continuously scales acute noxious mechanical sensitivity in nociceptive neurons and suppresses neuropathic pain transduction in a specific, light-touch-sensitive neuronal type recruited during mechanical allodynia. |
