| First Author | Kim Y | Year | 2013 |
| Journal | Dev Neurobiol | Volume | 73 |
| Issue | 9 | Pages | 702-12 |
| PubMed ID | 23696555 | Mgi Jnum | J:241828 |
| Mgi Id | MGI:5903698 | Doi | 10.1002/dneu.22092 |
| Citation | Kim Y, et al. (2013) Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development. Dev Neurobiol 73(9):702-12 |
| abstractText | EphAs and ephrin-As are expressed in multiple regions of the developing brain and have been implicated in regulating brain size. Here, we report the identification of a novel mechanism in which reverse signaling through ephrin-As controls neural epithelial cell number in the developing brain. Ectopic expression of EphA8-Fc in transgenic embryos induced apoptosis of neural epithelial cells, which was accompanied by a dramatic decrease in brain size. The number of ephrin-A5-expressing cells was significantly reduced in the brain region where EphA8-Fc was ectopically expressed. Furthermore, in vitro culture of the dissociated neuroepithelial cells revealed that EphA8-Fc enhanced apoptotic cell death of the ephrinA5-expressing cells in a caspase-dependent manner. Thus, our results suggest that reverse signaling through ephrin-As is biochemically linked with caspase-dependent proapoptotic signaling during early brain development. |
