| First Author | Russo MT | Year | 2004 |
| Journal | Cancer Res | Volume | 64 |
| Issue | 13 | Pages | 4411-4 |
| PubMed ID | 15231648 | Mgi Jnum | J:91208 |
| Mgi Id | MGI:3046124 | Doi | 10.1158/0008-5472.CAN-04-0355 |
| Citation | Russo MT, et al. (2004) Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases. Cancer Res 64(13):4411-4 |
| abstractText | The OGG1 and MYH DNA glycosylases prevent the accumulation of DNA 8-hydroxyguanine. In Myh(-/-) mice, there was no time-dependent accumulation of DNA 8-hydroxyguanine in brain, small intestine, lung, spleen, or kidney. Liver was an exception to this general pattern. Inactivation of both MYH and OGG1 caused an age-associated accumulation of DNA 8-hydroxyguanine in lung and small intestine. The effects of abrogated OGG1 and MYH on hepatic DNA 8-hydroxyguanine levels were additive. Because there is an increased incidence of lung and small intestine cancer in Myh(-/-)/Ogg1(-/-) mice, these findings support a causal role for unrepaired oxidized DNA bases in cancer development. |
