| First Author | Johri A | Year | 2012 |
| Journal | Hum Mol Genet | Volume | 21 |
| Issue | 5 | Pages | 1124-37 |
| PubMed ID | 22095692 | Mgi Jnum | J:180599 |
| Mgi Id | MGI:5306691 | Doi | 10.1093/hmg/ddr541 |
| Citation | Johri A, et al. (2012) Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease. Hum Mol Genet 21(5):1124-37 |
| abstractText | There is substantial evidence that impairment of peroxisome proliferator-activated receptor (PPAR)-gamma-coactivator 1alpha (PGC-1alpha) levels and activity play an important role in Huntington's disease (HD) pathogenesis. We tested whether pharmacologic treatment with the pan-PPAR agonist bezafibrate would correct a deficiency of PGC-1alpha and exert beneficial effects in a transgenic mouse model of HD. We found that administration of bezafibrate in the diet restored levels of PGC-1alpha, PPARs and downstream genes to levels which occur in wild-type mice. There were significant improvements in phenotype and survival. In the striatum, astrogliosis and neuronal atrophy were attenuated and numbers of mitochondria were increased. Bezafibrate treatment prevented conversion of type I oxidative to type II glycolytic muscle fibers and increased the numbers of muscle mitochondria. Finally, bezafibrate rescued lipid accumulation and apparent vacuolization of brown adipose tissue in the HD mice. These findings provide strong evidence that treatment with bezafibrate exerts neuroprotective effects which may be beneficial in the treatment of HD. |
