| First Author | Hamilton JA | Year | 2017 |
| Journal | J Immunol | Volume | 199 |
| Issue | 8 | Pages | 2618-2623 |
| PubMed ID | 28904124 | Mgi Jnum | J:254747 |
| Mgi Id | MGI:6103734 | Doi | 10.4049/jimmunol.1700888 |
| Citation | Hamilton JA, et al. (2017) Cutting Edge: Endogenous IFN-beta Regulates Survival and Development of Transitional B Cells. J Immunol 199(8):2618-2623 |
| abstractText | The transitional stage of B cell development is a formative stage in the spleen where autoreactive specificities are censored as B cells gain immune competence, but the intrinsic and extrinsic factors regulating survival of transitional stage 1 (T1) B cells are unknown. We report that B cell expression of IFN-beta is required for optimal survival and TLR7 responses of transitional B cells in the spleen and was overexpressed in T1 B cells from BXD2 lupus-prone mice. Single-cell gene expression analysis of B6 Ifnb(+/+) versus B6 Ifnb(--) T1 B cells revealed heterogeneous expression of Ifnb in wild-type B cells and distinct gene expression patterns associated with endogenous IFN-beta. Single-cell analysis of BXD2 T1 B cells revealed that Ifnb is expressed in early T1 B cell development with subsequent upregulation of Tlr7 and Ifna1 Together, these data suggest that T1 B cell expression of IFN-beta plays a key role in regulating responsiveness to external factors. |
