| First Author | Zhang BJ | Year | 2017 |
| Journal | Neuroscience | Volume | 340 |
| Pages | 258-267 | PubMed ID | 27815021 |
| Mgi Jnum | J:238272 | Mgi Id | MGI:5818984 |
| Doi | 10.1016/j.neuroscience.2016.09.053 | Citation | Zhang BJ, et al. (2017) Interleukin-1beta induces sleep independent of prostaglandin D2 in rats and mice. Neuroscience 340:258-267 |
| abstractText | Interleukin-1beta (IL-1beta) and prostaglandin (PG) D2 are endogenous sleep-promoting substances. Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. However, in the present study, pretreatment of rats with NS398 (3mg/kg) did not suppress the 64.2% increased non-rapid eye movement (non-REM, NREM) sleep during infusion of IL-1beta (10ng) for 6h in the nocturnal (active) period between 23:00 and 5:00 into the subarachnoid space of the PGD2-sensitive sleep-promoting zone of the basal forebrain. Meanwhile, IL-1beta at doses of 1.7 and 5mug/kg also significantly increased NREM sleep for 6h after intraperitoneal injection at 20:00 (light-off time) by 76.8% and 121.1%, respectively, in wild-type (WT) mice, by 67.7% and 147.3%, respectively, in WT mice pretreated with NS398 (5mg/kg) and by 108.9% and 121.6%, respectively, in PGD2 receptor (DP1R) knockout mice. These results indicate that IL-1beta-induced NREM sleep is independent of the PGD2/DP1R system and other COX-2-derived prostaglandins in rats and mice. |
