| First Author | Jin W | Year | 2002 |
| Journal | Neurosci Lett | Volume | 331 |
| Issue | 3 | Pages | 151-4 |
| PubMed ID | 12383919 | Mgi Jnum | J:108041 |
| Mgi Id | MGI:3622882 | Doi | 10.1016/s0304-3940(02)00872-8 |
| Citation | Jin W, et al. (2002) C-fos-deficient mouse hippocampal CA3 pyramidal neurons exhibit both enhanced basal and kainic acid-induced excitability. Neurosci Lett 331(3):151-4 |
| abstractText | Excitotoxicity is a process in which glutamate or other excitatory amino acids induce neuronal cell death. To address whether and how c-fos is involved in neuronal excitotoxicity, we previously generated mice in which the c-fos expression is eliminated specifically in the hippocampus. We found that these mutant mice exhibit increased kainic acid (KA)-induced seizure severity, increased neuronal excitability as measured by electroencephalogram, and increased neuronal cell death compared to wild-type control mice. To further assess the role of c-fos in regulating neuronal excitability at a cellular level, we performed hippocampal slice recording in the current study. We found that c-fos-deficient CA3 pyramidal neurons exhibit both enhanced basal and KA-induced excitability compared to normal control neurons. Our results suggest that c-fos regulates CA3 neuronal excitability. |
