| First Author | Fujishima Y | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 444 |
| Issue | 2 | Pages | 224-9 |
| PubMed ID | 24462873 | Mgi Jnum | J:219156 |
| Mgi Id | MGI:5619715 | Doi | 10.1016/j.bbrc.2014.01.043 |
| Citation | Fujishima Y, et al. (2014) Effect of adiponectin on cardiac beta-catenin signaling pathway under angiotensin II infusion. Biochem Biophys Res Commun 444(2):224-9 |
| abstractText | Obesity is associated with heart failure and cardiac hypertrophy. Adiponectin has been shown to play a protective role for cardiovascular diseases. The beta-catenin signaling pathway is deeply involved in cardiac hypertrophy. However, the effect of adiponectin on beta-catenin signaling has not been investigated in cardiac hypertrophy. Present study aimed to clarify the involvement of adiponectin and beta-catenin signaling pathway in the mouse model of angiotensin II (AngII)-induced cardiac hypertrophy. In hearts of Wild type (WT) mice, AngII dose-dependently augmented cytosolic beta-catenin protein level. WT and adiponectin knockout (Adipo-KO) mice were administered with AngII at 2.4 mg/kg/day for 14 days and were also injected with adenovirus expressing the adiponectin (Ad-Adipo) or the beta-galactosidase (Ad-betagal). Cardiac mRNA levels relating to hypertrophy and beta-catenin signaling were increased in Adipo-KO mice and these changes were reversed by Ad-Adipo. Phosphorylation of Akt was increased in Adipo-KO mice and such increases were reversed by Ad-Adipo. Furthermore, the phosphorylation of glycogen synthase kinase 3beta (GSK3beta) at Ser(9) and cytosolic beta-catenin level were increased in Adipo-KO mice and they were significantly reduced by Ad-Adipo treatment. Phosphorylation of mammalian target of rapamycin (mTOR) was reduced by Ad-Adipo-mediated adiponectin supplementation in WT and Adipo-KO mice. The current study suggests that adiponectin attenuates AngII-induced cardiac hypertrophic signals partly through Akt/GSK3beta/beta-catenin and Akt/mTOR pathways. |
