| First Author | Stephenson LM | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 12 | Pages | 8620-5 |
| PubMed ID | 17142761 | Mgi Jnum | J:140668 |
| Mgi Id | MGI:3814283 | Doi | 10.4049/jimmunol.177.12.8620 |
| Citation | Stephenson LM, et al. (2006) Vav proteins regulate the plasma cell program and secretory Ig production. J Immunol 177(12):8620-5 |
| abstractText | Plasma cell (PC) development is initiated following B cell activation and controlled by a B lymphocyte-induced maturation protein (Blimp)-1-dependent program involving the concerted action of several proplasma transcriptional regulators. However, the factors that control Blimp-1 expression remain largely unknown. In this context, mice deficient for all three of the Vav family of proteins (Vav(null)) develop substantial B cell populations, including marginal zone B cells, yet have a virtual absence of serum Igs, indicating that Vav may be specifically required in PC development and Ig production. We show in this study that mature marginal zone B cells from Vav(null) mice proliferate following stimulation with TLR ligands but exhibit severe defects in PC differentiation and Ig secretion. Under conditions inducing PC differentiation, Vav(null) B cells fail to efficiently induce Blimp-1, X box-binding protein-1, J chain, or secretory Ig mu transcripts but express IFN-regulatory factor-4 at levels similar to wild-type cells. These data indicate a previously unknown role for Vav as an upstream regulator of Blimp-1. |
