| First Author | Turner M | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 4 | Pages | 451-60 |
| PubMed ID | 9354466 | Mgi Jnum | J:79323 |
| Mgi Id | MGI:2387835 | Doi | 10.1016/s1074-7613(00)80367-2 |
| Citation | Turner M, et al. (1997) A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7(4):451-60 |
| abstractText | The T cell repertoire is shaped by positive and negative selection of thymocytes that express low levels of T cell receptor (TCR) and both CD4 and CD8. TCR-mediated signals that determine these selection processes are only partly understood. Vav, a GDP-GTP exchange factor for Rho-family proteins, is tyrosine phosphorylated following TCR stimulation, suggesting that it may transduce TCR signals. We now demonstrate that mice lacking Vav are viable and display a profound defect in the positive selection of both class I- and class II-restricted T cells. In contrast, Vav is not essential for negative selection, though in its absence negative selection is much less effective. Vav may influence the efficiency of TCR-induced selection events by regulating the intracellular calcium flux of thymocytes. |
