| First Author | Doody GM | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 6 | Pages | 542-7 |
| PubMed ID | 11376342 | Mgi Jnum | J:69807 |
| Mgi Id | MGI:2135488 | Doi | 10.1038/88748 |
| Citation | Doody GM, et al. (2001) Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol 2(6):542-7 |
| abstractText | B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor Vav-2. However, the immune responses to type II thymus-independent antigen as well as the primary response to thymus-dependent (TD) antigen are defective. Vav-2-deficient mice are also defective in their ability to switch immunoglobulin class, form germinal centers and generate secondary immune responses to TD antigens. Mice lacking both Vav-1 and Vav-2 contain reduced numbers of B lymphocytes and display a maturational block in the development of mature B cells. B cells from Vav-1(-/-)Vav-2(-/-) mice respond poorly to antigen receptor triggering, both in terms of proliferation and calcium release. These studies show the importance of Vav-2 in humoral immune responses and B cell maturation. |
