| First Author | Moran ST | Year | 2006 |
| Journal | Mol Immunol | Volume | 43 |
| Issue | 10 | Pages | 1694-9 |
| PubMed ID | 16256200 | Mgi Jnum | J:108115 |
| Mgi Id | MGI:3623052 | Doi | 10.1016/j.molimm.2005.09.009 |
| Citation | Moran ST, et al. (2006) Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol 43(10):1694-9 |
| abstractText | Protein kinase C-associated kinase (PKK; DIK/RIP4) is an ankyrin-repeat containing serine/threonine receptor-interacting protein (RIP)-family kinase that can activate NFkappaB, and is required for keratinocyte development. In earlier studies, the expression of a catalytically inactive mutant of PKK in the B cell lineage resulted in a marked decrease in peripheral B cells in the spleen and a severe reduction of B-1 B cells. Here we explore the consequences of a null mutation in PKK with respect to the generation of peripheral B cell lineages and the activation of NFkappaB. We show that PKK is not required for the production of B cells in the bone marrow or for the development and maintenance of all mature B lymphocyte populations. We also show that PKK is not required for the activation of NFkappaB downstream of the BCR, CD40, or TLR-4 in B cells. Taken together, these data demonstrate that the loss of this RIP-family kinase does not compromise B lymphocyte development and maintenance, but leaves open the possibility that PKK may have a redundant role in these processes. |
