| First Author | Schiemann B | Year | 2001 |
| Journal | Science | Volume | 293 |
| Issue | 5537 | Pages | 2111-4 |
| PubMed ID | 11509691 | Mgi Jnum | J:71681 |
| Mgi Id | MGI:2150560 | Doi | 10.1126/science.1061964 |
| Citation | Schiemann B, et al. (2001) An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293(5537):2111-4 |
| abstractText | The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA. |
