| First Author | Ichikawa H | Year | 2005 |
| Journal | Brain Res | Volume | 1036 |
| Issue | 1-2 | Pages | 192-5 |
| PubMed ID | 15725417 | Mgi Jnum | J:96212 |
| Mgi Id | MGI:3529713 | Doi | 10.1016/j.brainres.2004.10.028 |
| Citation | Ichikawa H, et al. (2005) Brn-3a deficiency increases tyrosine hydroxylase-immunoreactive neurons in the dorsal root ganglion. Brain Res 1036(1-2):192-195 |
| abstractText | Immunohistochemistry for tyrosine hydroxylase (TH) was performed on the dorsal root ganglia (DRG) in wild-type, heterozygous and Brn-3a knockout mice at embryonic day 18.5. TH-immunoreactive (-IR) neurons were detected in the DRG of wild-type and heterozygous mice, but their proportion was greatly increased by the loss of Brn-3a function (wild-type and heterozygot, 8.4%; knockout, 20.9%). IR neurons were of various sizes in wild-type (mean +/- S.D. = 118.1 +/- 55.4 mum(2), range = 26.6-306.3 mum(2)) and heterozygous mice. In the knockout mice, however, TH-IR neurons were mostly small (mean +/- S.D. = 68.2 +/- 34.3 mum(2), range = 11.8-166.8 mum(2)). The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons. |
