| Primary Identifier | MGI:2387933 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Myh6-Tpm2)1Dfw |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| description | Nine different founders were constructed with transgene copy numbers varying from 4 to 56. |
| molecularNote | The complete Tpm2 cDNA sequence and 3' untranslated region was used for the transgene. The transgene is expressed in adult heart tissue under the control of the Myhca promoter, which includes the 5' untranslated region and exons 1-3. Phosphoimaging analysis revealed a 150-fold and 34-fold increase in gene and protein expression, respectively, in hearts of transgenic animals. |
