| First Author | Veleva-Rotse BO | Year | 2014 |
| Journal | Neural Dev | Volume | 9 |
| Pages | 5 | PubMed ID | 24594058 |
| Mgi Jnum | J:207603 | Mgi Id | MGI:5559237 |
| Doi | 10.1186/1749-8104-9-5 | Citation | Veleva-Rotse BO, et al. (2014) STRAD pseudokinases regulate axogenesis and LKB1 stability. Neural Dev 9:5 |
| abstractText | BACKGROUND: Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is required for axon formation. It is allosterically regulated by two related and evolutionarily conserved pseudokinases, STe20-Related ADapters (STRADs) alpha and beta. The roles of STRADalpha and STRADbeta in the developing nervous system are not fully defined, nor is it known whether they serve distinct functions. RESULTS: We find that STRADalpha is highly spliced and appears to be the primal STRAD paralog. We report that each STRAD is sufficient for axogenesis and promoting cell survival in the developing cortex. We also reveal a reciprocal protein-stabilizing relationship in vivo between LKB1 and STRADalpha, whereby STRADalpha specifically maintains LKB1 protein levels via cytoplasmic compartmentalization. CONCLUSIONS: We demonstrate a novel role for STRADbeta in axogenesis and also show for the first time in vivo that STRADalpha, but not STRADbeta, is responsible for LKB1 protein stability. |
