| First Author | Gordon JA | Year | 2005 |
| Journal | J Neurosci | Volume | 25 |
| Issue | 28 | Pages | 6509-19 |
| PubMed ID | 16014712 | Mgi Jnum | J:99849 |
| Mgi Id | MGI:3584065 | Doi | 10.1523/JNEUROSCI.1211-05.2005 |
| Citation | Gordon JA, et al. (2005) State-dependent alterations in hippocampal oscillations in serotonin 1A receptor-deficient mice. J Neurosci 25(28):6509-19 |
| abstractText | Mice lacking the serotonin 1A receptor (5-HT(1A)R) show increased levels of anxiety-related behavior across multiple tests and background strains. Tissue-specific rescue experiments, lesion studies, and neurophysiological findings all point toward the hippocampus as a potential mediator of the phenotype. Serotonin, acting through 5-HT(1A)Rs, can suppress hippocampal theta-frequency oscillations, suggesting that theta oscillations might be increased in the knock-outs. To test this hypothesis, local field potential recordings were obtained from the hippocampus of awake, behaving knock-outs and wild-type littermates. The magnitude of theta oscillations was increased in the knock-outs, specifically in the anxiety-provoking elevated plus maze and not in a familiar environment or during rapid eye movement sleep. Theta power correlated with the fraction of time spent in the open arms, an anxiety-related behavioral variable. These results suggest a possible role for the hippocampus, and theta oscillations in particular, in the expression of anxiety in 5-HT(1A)R-deficient mice. |
