| Primary Identifier | MGI:2387444 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(SERPINA1-cre/ERT)1Ipc |
| Strain of Origin | Not Specified | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | This transgenic construct encodes a tamoxifen-inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to a sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain, to drive expression in hepatocytes. The ligand-binding domain possesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes. |
