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Publication : Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?

First Author  Sullivan BM Year  2013
Journal  J Virol Volume  87
Issue  7 Pages  4071-4
PubMed ID  23325690 Mgi Jnum  J:197218
Mgi Id  MGI:5491127 Doi  10.1128/JVI.03268-12
Citation  Sullivan BM, et al. (2013) Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?. J Virol 87(7):4071-4
abstractText  A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.
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