| First Author | Kim SM | Year | 2019 |
| Journal | FASEB J | Volume | 33 |
| Issue | 12 | Pages | 13386-13397 |
| PubMed ID | 31550172 | Mgi Jnum | J:297603 |
| Mgi Id | MGI:6472500 | Doi | 10.1096/fj.201901356R |
| Citation | Kim SM, et al. (2019) Axl is a key regulator of intestinal gammadelta T-cell homeostasis. FASEB J 33(12):13386-13397 |
| abstractText | Gut-homing gammadelta T cells are induced by chemokines and cell adhesion molecules and play a critical role in homeostasis and mucosal immunity; however, little is known regarding their upstream regulators. We investigated the role of Axl as a specific regulator of chemokines and cell adhesion molecule in the distribution of intestinal gammadelta T cells. The population of gammadelta T-cell receptor-positive cells including Vgamma1 and Vgamma7 subsets was remarkably increased in the intraepithelial lymphocytes of Axl(-/-) mice compared with those of wild-type (WT) mice. An increased number of migrated gammadelta T cells were observed in the coculture with intraepithelial cells from Axl(-/-) mice. The mRNA expression level of chemokine (C-C motif) ligand (CCL) 25 was specifically higher in the small intestine of Axl(-/-) mice than in WT mice. In adoptive transfer, the migration of both thymic and extrathymic gammadelta T cells was increased in Axl(-/-) mice. The activation of Axl signaling down-regulated CCL25 expression via ERK signaling pathway and reduced the population of gammadelta T cells. Systemic dissemination was suppressed in Axl(-/-) mice infected with Salmonella typhimurium. Thus, our findings suggest that Axl plays a critical role in regulating the migration of gammadelta T cells for the maintenance of homeostasis and bacterial resistance.-Kim, S.-M., Park, M., Yee, S.-M., Ji, K.-Y., Lee, E.-H., Nguyen, T.-V., Nguyen, T. H.-L., Jang, J., Kim, E.-M., Choi, H.-R., Yun, C.-H., Kang, H.-S. Axl is a key regulator of intestinal gammadelta T-cell homeostasis. |
