| First Author | Shao WH | Year | 2010 |
| Journal | Clin Immunol | Volume | 136 |
| Issue | 2 | Pages | 236-44 |
| PubMed ID | 20444650 | Mgi Jnum | J:162141 |
| Mgi Id | MGI:4462788 | Doi | 10.1016/j.clim.2010.04.002 |
| Citation | Shao WH, et al. (2010) A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clin Immunol 136(2):236-44 |
| abstractText | The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. In the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that downregulates inflammation. |
