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Allele : Nefh<tm2Dwc> neurofilament, heavy polypeptide; targeted mutation 2, Don W Cleveland
Primary Identifier  MGI:2387787 Allele Type  Targeted
Gene  Nefh Transmission  Germline
Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+> Is Recombinase  false
Is Wild Type  false
molecularNote  Sequence encoding the 612 carboxy terminal amino acids was deleted by a Myc-tagged neo cassette inserted by homologous recombination. Western blot analysis using antibodies directed toward the carboxy terminal and the Myc epitope tag showed the exclusive presence of truncated protein in sciatic and optic nerve extracts obtained from homozyous mutant mice.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • NR-Htaildelta,
  • NF-H<taildelta>,
  • NF-H<taildelta>,
  • NR-Htaildelta
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

9 Publication categories

Trail: Allele




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