| First Author | Le Borgne M | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 2 | Pages | e57137 |
| PubMed ID | 23431403 | Mgi Jnum | J:198304 |
| Mgi Id | MGI:5496321 | Doi | 10.1371/journal.pone.0057137 |
| Citation | Le Borgne M, et al. (2013) Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells. PLoS One 8(2):e57137 |
| abstractText | The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiation of helper and regulatory CD4+ T cells, as well as memory CD8+ T cells. In this study, we investigated the role of the ERK signaling pathway in regulating mTOR activation in T cells. We showed that activation of ERK following TCR engagement is required for sustained mTOR complex 1 (mTORC1) activation. Absence of kinase suppressor of Ras 1 (KSR1), a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased mTORC1 activity following T cell activation. However, KSR1-deficient mice displayed normal regulatory CD4+ T cell development, as well as normal memory CD8+ T cell responses to LCMV and Listeria monocytogenes infection. These data indicate that despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation. |
