| First Author | Liu X | Year | 2016 |
| Journal | Dev Cell | Volume | 38 |
| Issue | 3 | Pages | 275-90 |
| PubMed ID | 27453502 | Mgi Jnum | J:263401 |
| Mgi Id | MGI:6189323 | Doi | 10.1016/j.devcel.2016.06.019 |
| Citation | Liu X, et al. (2016) PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/beta1-Integrin Signaling. Dev Cell 38(3):275-90 |
| abstractText | Alterations in dendritic spine numbers are linked to deficits in learning and memory. While we previously revealed that postsynaptic plasticity-related gene 1 (PRG-1) controls lysophosphatidic acid (LPA) signaling at glutamatergic synapses via presynaptic LPA receptors, we now show that PRG-1 also affects spine density and synaptic plasticity in a cell-autonomous fashion via protein phosphatase 2A (PP2A)/beta1-integrin activation. PRG-1 deficiency reduces spine numbers and beta1-integrin activation, alters long-term potentiation (LTP), and impairs spatial memory. The intracellular PRG-1 C terminus interacts in an LPA-dependent fashion with PP2A, thus modulating its phosphatase activity at the postsynaptic density. This results in recruitment of adhesome components src, paxillin, and talin to lipid rafts and ultimately in activation of beta1-integrins. Consistent with these findings, activation of PP2A with FTY720 rescues defects in spine density and LTP of PRG-1-deficient animals. These results disclose a mechanism by which bioactive lipid signaling via PRG-1 could affect synaptic plasticity and memory formation. |
